Key result
In detergent-skinned swine carotid media, free Mg2+ (3-20 mM) caused an increase in shortening velocity and concentration-dependent stress without detectable myosin light chain phosphorylation.
Population
Triton X-100-skinned swine carotid media
Comparison
Free Mg2+ (3-20 mM) vs Absence of Ca2+ / known characteristics of…
Design
Preclinical
Authors
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Supports Mg2+-dependent latch-bridge formation in vascular smooth muscle; hypothesis-generating for human vascular regulation.
High concentrations of magnesium directly induce latch-bridge formation in vascular smooth muscle, supporting a regulatory system independent of MLC phosphorylation.
Moreland et al. (1991) studied this question. Free Mg2+ was evaluated on Velocity of shortening and stress development. In detergent-skinned swine carotid media, free Mg2+ (3-20 mM) caused an increase in shortening velocity and concentration-dependent stress without detectable myosin light chain phosphorylation.
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