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July 1, 1992Journal of the American Chemical Society

Catalytic and regioselective acylation of aromatic heterocycles using carbon monoxide and olefins

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Authors

EMEric J. MooreAstraZeneca (France)WPW. R. PretzerCare ResourceTOTodd J. O'ConnellExact Sciences (United States)

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Implication

Experimental study demonstrates catalytic regioselective acylation of aromatic heterocycles with carbon monoxide and olefins, highlighting a direct pathway to functionalized heterocyclic ketones.

Key Points

  • Develop a direct transition-metal-catalyzed method for the regioselective acylation of aromatic heterocycles using carbon monoxide and olefins.
  • Coupled aromatic heterocycles with olefins and carbon monoxide in the presence of a catalyst.
  • Evaluated reaction conditions to control regiochemical substitution on heteroaromatic substrates.
  • Demonstrated direct catalytic carbonylation of aromatic heterocycles using carbon monoxide and olefin partners.
  • Achieved high regioselectivity in the formation of acylated heteroaromatic ketone products without prefunctionalized acylating reagents.

Cite This Study

Moore et al. (1992) studied this question.

synapsesocial.com/papers/6a70282e26a7f98052dcaa41https://doi.org/10.1021/ja00040a078
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