Why the study?
Does l-753037 reduce infarct size in a canine model of acute coronary artery occlusion and reperfusion?
Population
18 instrumented dogs in a model of canine coronary artery occlusion and reperfusion
Comparison
l-753037 by intracoronary infusion 30 minutes… vs Vehicle by intracoronary infusion
Design
Preclinical, randomized
Follow-up
4 hours of reperfusion
Authors
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Limits infarct size in canine ischemia-reperfusion; leaves open whether endothelin antagonism reduces human myocardial injury.
Does l-753037 reduce infarct size in a canine model of acute coronary artery occlusion and reperfusion?
In a canine model of coronary occlusion, the non-selective endothelin antagonist l-753037 significantly reduced infarct size and improved regional myocardial flow.
Krause et al. (2004) studied this question.
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