April 3, 1998Science

Structural Conservation in Prokaryotic and Eukaryotic Potassium Channels

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Population

Mutant K+ channels from Streptomyces lividans

Design

Preclinical

Authors

RMRoderick MacKinnonElectrophysiology SCSteven L. CohenUniversity of Pittsburgh AKAnling KuoUniversity of Toronto

Discussion

Member takes

Implication

Bacterial K+ channel models may aid drug design; leaves open translation to human cardiovascular therapies.

Structured PICO

Population

Mutant K+ channels from Streptomyces lividans

Intervention

Toxins from scorpion venom (Leiurus quinquestriatus hebraeus), specifically agitoxin2

Outcome

Pore structure conservation between prokaryotic and eukaryotic K+ channels

Demonstrates structural conservation of the pore structure between prokaryotic and eukaryotic K+ channels, offering a new approach for K+ channel pharmacology.

Cite This Study

MacKinnon et al. (1998) studied this question.

synapsesocial.com/papers/6a7028708031ec7bb1dc28de https://doi.org/10.1126/science.280.5360.106

View Full Paper

Ask AI

Bookmark

Structural Conservation in Prokaryotic and Eukaryotic Potassium Channels

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Structural Conservation in Prokaryotic and Eukaryotic Potassium Channels

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider