Population
Peripheral blood mononuclear cells and polymorphonuclear leukocytes in an in vitro cell culture model
Comparison
Co-culture with varying PMN/PBMC ratios, with or… vs PBMC cultured alone
Design
Preclinical
Follow-up
20 hours
Authors
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PMN biphasic TF effects should not yet inform clinical thrombosis management; hypothesis-generating for concentration-dependent leukocyte interactions.
Polymorphonuclear leukocytes exert a concentration-dependent, biphasic regulatory effect on tissue factor production by mononuclear cells, mediated by reactive oxygen species at low concentrations and direct cell contact at high concentrations.
Cadroy et al. (2000) studied this question.
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