Key result
EPCR localizes selectively to large-vessel endothelium, while thrombomodulin spans both large vessels and capillaries.
Why the study?
The relationship between thrombomodulin and EPCR expression on endothelium and their tissue distributions was not fully understood.
Population
Human and baboon tissues
Comparison
EPCR expression vs thrombomodulin expression
Design
Immunohistochemistry study
Authors
Loading...
May explain vessel-size differences in protein C pathway activity; extends mapping data but leaves open clinical translation.
The high expression of EPCR on arterial vessels suggests it enhances protein C activation on large vessels, potentially explaining why partial protein C deficiency is a weak risk factor for arterial thrombosis.
Lászik et al. (1997) studied this question. EPCR and thrombomodulin expression was evaluated on Cellular specificity and tissue distributions of EPCR and thrombomodulin. EPCR expression was detected almost exclusively on the endothelium of large blood vessels (arteries and veins), whereas thrombomodulin was found in both large vessels and capillary endothelium.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: