Why the study?
Many tyrosine kinase inhibitors prescribed for long-term cancer treatment cause cardiotoxicity with limited cure, and the molecular mechanisms needed clarification to identify therapeutic targets.
Endoplasmic reticulum stress and subsequent inflammation are key mechanisms underlying cardiotoxicity induced by specific tyrosine kinase inhibitors, offering a potential therapeutic target to mitigate cardiac damage.
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May guide TKI selection via ER stress monitoring; leaves open clinical validation of targeted cardioprotection.
Wang et al. (2023) studied this question.
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