Why the study?
Does body mass index classification affect the required unfractionated heparin infusion rate per kilogram of actual body weight to achieve therapeutic aPTT?
Does body mass index classification affect the required unfractionated heparin infusion rate per kilogram of actual body weight to achieve therapeutic aPTT?
Morbidly obese patients require smaller unfractionated heparin infusion rates per kilogram of actual body weight to achieve therapeutic aPTT compared to patients with lower body mass indices.
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May support lower per-kg UFH infusion rates in class III obesity; extends observational data but leaves practice change open pending prospective trials.
Riney et al. (2010) studied this question.
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