What question did this study set out to answer?

To determine the role of beta-adrenergic receptor activation in producing cardiac and aortic arch malformations during early chick embryo development.

August 1, 1975Teratology

The role of β‐adrenergic activity in the production of cardiac and aortic arch anomalies in chick embryos

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To determine the role of beta-adrenergic receptor activation in producing cardiac and aortic arch malformations during early chick embryo development.
Administered single in ovo doses (0.4 × 10⁻⁹ to 20 × 10⁻⁹ mol/5 µL saline) of isoproterenol, epinephrine, norepinephrine, or phenylephrine to chick embryos at Hamburger-Hamilton stages 20–27.
Pretreated a subset of embryos with the beta-adrenergic antagonist propranolol prior to isoproterenol administration to assess protective receptor blockade.
A total of 743 cardiovascular anomalies were generated, with anomaly rates higher in all treated groups than in vehicle controls.
Defect frequencies correlated directly with the beta-adrenergic potency of each compound and were significantly attenuated by propranolol pretreatment.
Observed malformations included aortic arch defects, ventricular septal defects, double outlet right ventricle, aortic hypoplasia, and truncus arteriosus.

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Implication

Experimental study demonstrates sympathomimetic amines induce cardiovascular defects in chick embryos, indicating beta-adrenergic activation directly drives malformations.

Cite This Study

Hodach et al. (1975) studied this question.

synapsesocial.com/papers/6a702d2831a3df82432873a4 https://doi.org/10.1002/tera.1420120105

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Implication

Experimental study demonstrates sympathomimetic amines induce cardiovascular defects in chick embryos, indicating beta-adrenergic activation directly drives malformations.

The role of β‐adrenergic activity in the production of cardiac and aortic arch anomalies in chick embryos

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Discussion

Implication

Cite This Study

The role of β‐adrenergic activity in the production of cardiac and aortic arch anomalies in chick embryos

Key Points

Discussion

Implication

Cite This Study

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