Why the study?
Does prolonged exercise (a marathon race) alter left ventricular diastolic function in human subjects?
Population
29 subjects (age 18-62 years) who volunteered to participate in a marathon race
Comparison
Prolonged exercise (marathon race) vs Pre-race baseline (self-controlled)
Design
Cohort
Follow-up
Immediate post-race
Authors
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Marathon running was associated with transient LV diastolic impairment; hypothesis-generating for athlete monitoring and mechanisms.
Does prolonged exercise (a marathon race) alter left ventricular diastolic function in human subjects?
Prolonged exercise during a marathon race induces a transient depression in left ventricular diastolic function, likely due to altered myocardial relaxation rather than changes in preload or myocyte damage.
George et al. (2005) studied this question.
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