March 15, 1997Journal of Clinical InvestigationOpen Access

The endothelial cell ecto-ADPase responsible for inhibition of platelet function is CD39.

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Population

Human umbilical vein endothelial cells (HUVEC), COS cells, MP-1 cells, and platelet-rich plasma

Design

Preclinical

Authors

AMAaron J. MarcusCornell University MBM. Johan BroekmanCornell University JDJoan H.F. DrosopoulosCornell University

Discussion

Member takes

Implication

CD39 may be a novel antithrombotic target; leaves open whether modulation improves outcomes in vivo.

Structured PICO

Population

Human umbilical vein endothelial cells (HUVEC), COS cells, MP-1 cells, and platelet-rich plasma

Intervention

Transfection of COS cells with human CD39; immunoprecipitation with monoclonal antibodies to CD39

Outcome

Identification of endothelial ecto-ADPase as CD39 and demonstration of its ability to inhibit ADP-induced platelet aggregationsurrogate

The identification of CD39 as the endothelial ecto-ADPase responsible for inhibiting platelet reactivity provides a potential new target for antithrombotic therapies.

Cite This Study

Marcus et al. (1997) studied this question.

synapsesocial.com/papers/6a702e58a528af2d65c36086 https://doi.org/10.1172/jci119294

Topics

Dual antiplatelet therapy

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The endothelial cell ecto-ADPase responsible for inhibition of platelet function is CD39.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

The endothelial cell ecto-ADPase responsible for inhibition of platelet function is CD39.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider