Key result
Cardiogel enhances murine mesenchymal stem cell proliferation, differentiation, and survival under oxidative stress.
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Cultured murine bone marrow derived mesenchymal stem cells (BMSC) when grown along with cardiogel derived from mouse cardiac fibroblast, exhibited increased cell proliferation and differentiation and enhanced survival under oxidative stress induced by the exposure of H2O2 in vitro (similar to in vivo ischemia like condition). Adhesion of BMSC to the cardiogel occurred at a faster rate when compared to the cells grown on normal surface. BMSC attached to cardiogel showed an increased resistance to proteolytic (enzymatic) disassociation. This is the first report on an attempt to use an in house biomaterial for the growth of BMSC that led to their heightened resistance towards oxidative stress. These studies support that cardiogel is an efficient biodegradable three-dimensional extracellular matrix which supports better growth of BMSC and can be used as a scaffold for stem cell delivery, with potential therapeutic applications in cardiac tissue regeneration.
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Sreejit et al. (2011) studied Cardiac tissue regeneration (in vitro). Cardiogel derived from mouse cardiac fibroblast vs. Normal culture surface was evaluated on Cell proliferation, differentiation, survival under oxidative stress, and adhesion rate. Murine mesenchymal stem cells grown on cardiogel exhibited increased proliferation, differentiation, and survival under oxidative stress compared to normal surfaces.
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