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November 9, 2021Frontiers in EndocrinologyOpen Access

Patients with T2D presented lower parasympathetic modulation at rest and slowed HRR after physical exercise compared to controls; fasting glycemia was a predictor of cardiac autonomic involvement.

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Why the study?

Chronic hyperglycemia is associated with cardiac autonomic dysfunction assessed by HRV and HRR, which are linked to severe cardiovascular outcomes.

Does Type 2 diabetes impair cardiac autonomic modulation as measured by HRV and HRR in middle-aged adults?

Comparison

Diabetes group (n = 59) vs control group (n = 34)

Design

Observational case-control study

Authors

LSLucas SilvaPGPaulo GentilCSC Seguro

Discussion

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Overview

High fasting glycemia may impair autonomic function in T2D; leaves open whether tighter control improves HRV/HRR.

Structured PICO

Does Type 2 diabetes impair cardiac autonomic modulation as measured by HRV and HRR in middle-aged adults?

P
Population
93 middle-aged adults, stratified into a control group (n=34) and a diabetes group (n=59)
I
Intervention
Type 2 diabetes (exposure)
C
Comparator
Control group without Type 2 diabetes
O
Outcome
Cardiac autonomic modulation assessed by heart rate variability (HRV) and heart rate recovery (HRR)surrogate

Type 2 diabetes and higher fasting glycemia are associated with impaired cardiac autonomic control, evidenced by reduced HRV and slowed HRR, which may increase cardiovascular risk.

Cite This Study

Silva et al. (2021) studied this question.

synapsesocial.com/papers/6a702eaeac440176ef28d3fdhttps://doi.org/10.3389/fendo.2021.760292
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Poor glycemic control impacts linear and non-linear dynamics of heart rate in DM type 22015 · 10 citations
  2. 2Sympathetic Overactivity and Parasympathetic Impairment in Type 2 Diabetes: An Analysis of Cardiovascular Autonomic Functions2024 · 6 citations
  3. 3Evaluation of cardiac autonomic dysfunction using electrocardiography in type 2 diabetes mellitus patients: a case-control study2025
  4. 4Hyperglycemia: A determinant of cardiac autonomic dysfunction in youth with obesity across the spectrum of glycemic regulation2023 · 10 citations
  5. 5Impact of blood glucose control on sympathetic and vagus nerve functional status in patients with type 2 diabetes mellitus2019 · 27 citations