Population
Normal and combined lipase deficiency (cld) pups and adult mice
Comparison
In situ hybridization for LPL mRNA using an… vs Normal littermates
Design
Preclinical
Authors
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LPL expression persists despite enzymatic deficiency in mice; leaves open transcriptional vs. post-transcriptional mechanisms in human hypertriglyceridemia.
LPL gene expression and distribution are unaffected by the combined lipase deficiency mutation, despite the lack of LPL enzymatic activity and elevated plasma triglycerides.
Yacoub et al. (1990) studied this question.
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