What question did this study set out to answer?

To elucidate the mechanisms regulating the functional expression of endothelial-bound lipases and their role in lipoprotein metabolism and atherogenesis.

April 1, 1986Drug Development Research

Endothelial bound lipases and lipoprotein metabolism in disease and drug development

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Authors

KOKazuhiro OkaBaylor College of Medicine JPJames R. PaternitiSt. Michael's Hospital

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Implication

Mouse model of combined lipase deficiency may clarify endothelial lipase regulation; leaves open therapeutic targeting in atherosclerosis.

Key Points

To elucidate the mechanisms regulating the functional expression of endothelial-bound lipases and their role in lipoprotein metabolism and atherogenesis.
Investigated lipoprotein lipase and hepatic triglyceride lipase activity using a mutant mouse model harboring an autosomal recessive combined lipase deficiency (cld) mutation.
Examined postsynthetic cellular processing, transport, and functional expression of lipolytic enzymes at the vascular endothelial surface.
The cld mutation causes a combined deficiency in both lipoprotein lipase and hepatic triglyceride lipase activities.
Deficiency is driven by defective postsynthetic cellular processes that prevent newly synthesized lipases from reaching functional expression on the lumenal endothelial surface.

Cite This Study

Oka et al. (1986) studied this question.

synapsesocial.com/papers/6a702fd55d37378ac1dd4175 https://doi.org/10.1002/ddr.430070408

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Implication

Mouse model of combined lipase deficiency may clarify endothelial lipase regulation; leaves open therapeutic targeting in atherosclerosis.

Endothelial bound lipases and lipoprotein metabolism in disease and drug development

Discussion

Member takes

Implication

Key Points

Cite This Study

Endothelial bound lipases and lipoprotein metabolism in disease and drug development

Discussion

Member takes

Implication

Key Points

Cite This Study

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