Lactobacillus gasseri NK109 Alleviates Lipopolysaccharide-Induced Cognitive Impairment in Mice by Up-Regulating Inflammation-Mediated BDNF Expression

This is the authors' abstract. We don't add key points for this paper.

Exposure to lipopolysaccharide (LPS) causes cognitive impairment (CI). In the preliminary study, Lactobacillus gasseri NK109 suppressed LPS-induced expression of proinflammatory cytokines in macrophages. Therefore, the effect of NK109 on LPS-increased CI was investigated in mice. Intraperitoneal injection of LPS caused CI-like behaviors and neuroinflammation. However, orally administered NK109 reduced LPS-increased CI-like behaviors and hippocampal IL-1β and TNF-α expression, whereas LPS-decreased BDNF expression increased. NK109 also reduced LPS-increased colonic myeloperoxidase, IL-1β, and TNF-α expression. The efficacy of NK109 was increased by the combination of soybean embryo ethanol extract (SE). These findings suggest that NK109 with SE can improve CI by alleviating inflammation-mediated BDNF expression, thereby being beneficial for dementia therapy.