What question did this study set out to answer?

To investigate whether coagulation factor X is locally produced in injured lung tissue and how it mechanistically drives pulmonary fibrosis.

August 3, 2009Journal of Clinical InvestigationOpen Access

Increased local expression of coagulation factor X contributes to the fibrotic response in human and murine lung injury

View Full Paper

Ask AI

Bookmark

Authors

CSChris J. ScottonUniversity of Exeter MKMalvina A. KrupiczojcQueen Mary University of London MKMélanie KönigshoffUniversity of Pittsburgh

Discussion

Member takes

Implication

Preclinical study demonstrates that local coagulation factor X expression promotes pulmonary fibrosis via PAR1 signaling, highlighting a direct target for treating fibrotic lung diseases.

Key Points

To investigate whether coagulation factor X is locally produced in injured lung tissue and how it mechanistically drives pulmonary fibrosis.
Evaluated factor X expression and colocalization of PAR1, alphavbeta5, and alpha-SMA in lung biopsies from individuals with idiopathic pulmonary fibrosis and murine fibrosis models.
Treated cultured primary human adult lung fibroblasts with FXa to assess myofibroblast differentiation and TGF-beta activation.
Administered a direct FXa inhibitor in a bleomycin-induced pulmonary fibrosis mouse model to assess therapeutic response.
Factor X expression was markedly elevated locally within bronchial and alveolar epithelia in both human and murine fibrotic lung tissue.
FXa potently induced myofibroblast differentiation in primary human lung fibroblasts through TGF-beta activation mediated by PAR1 and integrin alphavbeta5, which colocalized within fibrotic foci.
Direct pharmacological inhibition of FXa significantly attenuated bleomycin-induced pulmonary fibrosis in mice.

Cite This Study

Scotton et al. (2009) studied this question.

synapsesocial.com/papers/6a70301c26a7f98052dcb1aa https://doi.org/10.1172/jci33288

View Full Paper

Ask AI

Bookmark

Implication

Preclinical study demonstrates that local coagulation factor X expression promotes pulmonary fibrosis via PAR1 signaling, highlighting a direct target for treating fibrotic lung diseases.

Increased local expression of coagulation factor X contributes to the fibrotic response in human and murine lung injury

Discussion

Member takes

Implication

Key Points

Cite This Study

Increased local expression of coagulation factor X contributes to the fibrotic response in human and murine lung injury

Discussion

Member takes

Implication

Key Points

Cite This Study

Also Consider

Also Consider