This review summarizes the synthesis and biomedical applications of stimuli-responsive elastin-like polypeptides.
ELPs remain investigational for clinical use; review extends synthesis of methods for drug delivery and tissue engineering.
Elastin-like polypeptides (ELPs) are artificial biopolymers composed of the pentapeptide repeat Val-Pro-Gly-Xaa-Gly. They are a class of stimuli responsive biopolymers exhibiting an inverse temperature transition, which are particularly attractive in biological applications. In this paper, the methods of synthesizing ELPs and the applications in medicine and biotechnology such as purification of fusion proteins, drug delivery, and tissue engineering are reviewed. In addition, further perspective will be presented.
No takes yet. Share an insight, caveat, or question.
Shang et al. (2013) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: