Key result
Labetalol improves blood pressure control and renal outcomes over Aldomet in pregnancy-induced hypertension.
RCT (n=26)
Twentysix women with pregnancy-induced hypertension have been randomly treated with either labetalol or Aldomet. A more satisfactory control of blood pressure was obtained with labetalol with minimal side-effects. After two weeks of treatment with labetalol renal function had significantly improved with a markedly lower incidence of proteinuria. More patients went into spontaneous labour following labetalol than following Aldomet; the Bishop score was also higher in this group. No adverse effects attributable to labetalol were noted in the baby either ante- or post-natally.
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Lamming et al. (1980) conducted an RCT in Moderate and severe pregnancy-induced hypertension (n=26). Labetalol vs. Methyl Dopa (Aldomet) was evaluated on Blood pressure control. Labetalol achieved more satisfactory blood pressure control, improved renal function, and lower incidence of proteinuria compared to Aldomet in women with pregnancy-induced hypertension.
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