What is the clinical evidence from this study?

Study design: Other. Intervention: AH 5158 vs. Propranolol and phentolamine. Primary outcome: Adrenoceptor blockade and cardiovascular effects.

August 1, 1972British Journal of PharmacologyOpen Access

Pharmacology of AH 5158; a drug which blocks both α‐ and β‐adrenoceptors

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Key result

AH 5158 produces competitive blockade of both alpha- and beta-adrenoceptors, demonstrating a novel pharmacological profile with potential applications in cardiovascular disorders.

Population

Preclinical models including anaesthetized dogs, spinal dogs, guinea-pig left atrial strips, syrosingopine…

Comparison

AH 5158 (administered intravenously or orally) vs Propranolol and phentolamine

Design

Preclinical

Authors

JFJ B FarmerPfizer (United Kingdom)IKI. KennedyUniversity of East London GLGerhard LevyUniversity of Florida

Discussion

Member takes

Implication

Warrants no change in clinical practice; leaves open whether dual alpha-beta blockade translates to human cardiovascular therapy.

Structured PICO

Population

Preclinical models including anaesthetized dogs, spinal dogs, guinea-pig left atrial strips, syrosingopine pre-treated dogs, open chest dogs, and conscious renal hypertensive dogs

Intervention

AH 5158 (administered intravenously or orally)

Comparator

Propranolol and phentolamine

Outcome

Alpha- and beta-adrenoceptor blockade potency and hemodynamic effects (cardiac output, rate, contractility, peripheral resistance, blood pressure)surrogate

AH 5158 demonstrates a novel pharmacological profile by blocking both alpha- and beta-adrenoceptors, lowering blood pressure and peripheral resistance in animal models.

Cite This Study

Farmer et al. (1972) studied this question. AH 5158 vs. Propranolol and phentolamine was evaluated on Adrenoceptor blockade and cardiovascular effects. AH 5158 produces competitive blockade of both alpha- and beta-adrenoceptors, demonstrating a novel pharmacological profile with potential applications in cardiovascular disorders.

synapsesocial.com/papers/6a8d5a560db1783955dcd6c3 https://doi.org/10.1111/j.1476-5381.1972.tb08125.x

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Pharmacology of AH 5158; a drug which blocks both α‐ and β‐adrenoceptors

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Pharmacology of AH 5158; a drug which blocks both α‐ and β‐adrenoceptors

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider