Key result
Single oral doses of AH 5158 (100-400 mg) produced dose-related inhibition of exercise-induced tachycardia and falls in blood pressure in healthy male volunteers.
Why the study?
Does oral AH 5158 reduce exercise-induced tachycardia and blood pressure in healthy male volunteers?
Population
Healthy male volunteers
Follow-up
8 hours (duration of action)
Authors
Loading...
Dual α/β antagonism shown in healthy volunteers; leaves open translation to patient care.
Does oral AH 5158 reduce exercise-induced tachycardia and blood pressure in healthy male volunteers?
AH 5158 demonstrates combined alpha- and beta-adrenoceptor antagonism, suggesting potential as an antihypertensive drug.
Richards et al. (1974) studied Healthy volunteers. AH 5158 was evaluated on Inhibition of exercise induced tachycardia and falls in systolic and diastolic pressure. Single oral doses of AH 5158 (100-400 mg) produced dose-related inhibition of exercise-induced tachycardia and falls in blood pressure in healthy male volunteers.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: