January 1, 1987British Journal of Clinical PharmacologyOpen Access

Immediate haemodynamic effects of a novel partial agonist, beta 1‐ adrenoceptor blocking drug ICI 141,292 after intravenous administration to healthy young volunteers and patients with ischaemic heart disease.

View Full Paper

Ask AI

Bookmark

Why the study?

Does intravenous ICI 141,292 alter immediate haemodynamic parameters compared to atenolol in healthy volunteers and patients with ischaemic heart disease?

Population

8 healthy young volunteers and 6 patients with ischaemic heart disease (total n=14)

Comparison

Intravenous ICI 141,292 vs Intravenous atenolol 5 mg (in healthy volunteers)

Design

RCT, randomised crossover, double-blind

Follow-up

Immediate

Authors

JBJan BondeStatens Serum Institut TSTage Lysbo SvendsenDiakonhjemmet Hospital KLKeld LyngborgAalborg University Hospital

Discussion

Member takes

Implication

Supports acute beta1-blockade with ISA for exercise HR control in IHD; extends haemodynamic data on this agent versus healthy volunteers.

Structured PICO

Does intravenous ICI 141,292 alter immediate haemodynamic parameters compared to atenolol in healthy volunteers and patients with ischaemic heart disease?

Population

8 healthy young volunteers and 6 patients with ischaemic heart disease (total n=14)

Intervention

Intravenous ICI 141,292 (1, 2, and 4 mg in healthy volunteers; sequential doses of 0.5, 0.5, 1.0, and 2.0 mg in ischaemic heart disease patients)

Comparator

Intravenous atenolol 5 mg (in healthy volunteers)

Outcome

Immediate haemodynamic effects including heart rate, blood pressure, cardiac output, stroke volume, total peripheral resistance, and mean pulmonary arterial pressuresurrogate

ICI 141,292 is a potent beta 1-adrenoceptor blocking agent with moderate intrinsic sympathomimetic activity that effectively reduces heart rate and blood pressure during exercise.

Cite This Study

Bonde et al. (1987) studied this question.

synapsesocial.com/papers/6a8febc736a836210333c33e https://doi.org/10.1111/j.1365-2125.1987.tb03006.x

View Full Paper

Ask AI

Bookmark

Immediate haemodynamic effects of a novel partial agonist, beta 1‐ adrenoceptor blocking drug ICI 141,292 after intravenous administration to healthy young volunteers and patients with ischaemic heart disease.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Immediate haemodynamic effects of a novel partial agonist, beta 1‐ adrenoceptor blocking drug ICI 141,292 after intravenous administration to healthy young volunteers and patients with ischaemic heart disease.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider