Population
Dog heart preparation in which cardiovascular reflexes were prevented from occurring
Comparison
ICI 118,587 (1--3-beta- ethylamino-2-propranol… vs Isoprenaline and noradrenaline
Design
Preclinical
Authors
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Supports preclinical testing of beta-1 partial agonists; leaves open translation to human therapy.
ICI 118,587 is a selective beta-1 adrenoceptor partial agonist with direct chronotropic and inotropic effects on the heart but no direct effects on vascular smooth muscle.
Nuttall et al. (1982) studied this question.
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