Key result
ICI 50,172 prevented the inotropic effects of intra-coronary isoprenaline, adrenaline, and noradrenaline, and blocked or reversed the coronary dilator effect of adrenaline and noradrenaline.
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Supports targeted adrenergic blockade in cardiac responses; extends early pharmacologic data but leaves open clinical translation.
Ross et al. (1970) studied this question. ICI 50,172 was evaluated on Inotropic effects and coronary vasodilator action. ICI 50,172 prevented the inotropic effects of intra-coronary isoprenaline, adrenaline, and noradrenaline, and blocked or reversed the coronary dilator effect of adrenaline and noradrenaline.
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