Key result
Higher CSF smooth-muscle constrictor levels linked to severe vasospasm and death after subarachnoid hemorrhage.
Observational (n=38)
Cerebrospinal fluid (CSF) was collected preoperatively (by lumbar puncture) or perioperatively (by lumbar or ventricular drain) from 32 patients with subarachnoid hemorrhage (SAH) from ruptured intracranial aneurysms. Samples were also obtained from six control patients without evidence of subarachnoid blood. Smooth-muscle constrictor activity in the CSF was measured by bioassay using the isolated rat stomach fundus preparation. Concentrations of unidentified smooth-muscle constrictor substances were considerably greater in CSF from a group of seven patients with evidence of severe angiographic vasospasm and/or delayed ischemic deficits who died (73.8 +/- 39.7 nmol/liter prostaglandin E2 (PGE2) equivalents), as compared to 25 other SAH patients who survived (6.5 +/- 1.4 nmol/liter PGE2 equivalents), and six control patients (1.17 +/- 0.34 nmol/liter PGE2 equivalents). The data suggest that there is a relationship between smooth-muscle constrictor substances in the CSF after SAH and both the degree of angiographic vasospasm and the outcome. It is possible that this relationship might be exploited clinically.
No takes yet. Share an insight, caveat, or question.
Kaye et al. (1984) conducted an observational in Subarachnoid hemorrhage (SAH) (n=38). CSF smooth-muscle constrictor activity vs. Surviving SAH patients and non-SAH controls was evaluated on Degree of angiographic vasospasm and mortality. CSF smooth-muscle constrictor substance concentrations were higher in SAH patients who died with severe vasospasm (73.8 nmol/L) than in SAH survivors (6.5 nmol/L) and controls (1.17 nmol/L).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: