Key result
Subarachnoid haemorrhage CSF contains an unidentified substance that constricts the basilar artery, driving cerebral vasospasm.
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Demonstrates that cerebrospinal fluid from subarachnoid hemorrhage patients contracts the basilar artery, indicating a causative vasoactive substance in cerebral arterial spasm.
Cerebrospinal fluid from patients with subarachnoid haemorrhage and cerebral arterial spasm contracted the isolated basilar artery and potentiated contractions produced by 5-hydroxytryptamine, noradrenaline, and six prostaglandins. The unidentified substance in cerebrospinal fluid probably plays a role in the aetiology of cerebral arterial spasm.
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Boullin et al. (1976) studied this question. Cerebrospinal fluid from patients with subarachnoid haemorrhage contains an unidentified vasoactive substance that contracts the basilar artery and likely contributes to cerebral arterial spasm.
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