Why the study?
Does subarachnoid hemorrhage impair endothelium-dependent relaxation in human basilar arteries?
Population
Human basilar arteries obtained from subjects who died within 1 day after subarachnoid hemorrhage and…
Comparison
Subarachnoid hemorrhage (ex vivo tissue analysis) vs Control subjects who died from causes other than…
Design
Preclinical
Authors
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Endothelial dysfunction may contribute to SAH vasospasm; leaves open translation to human basilar arteries and clinical outcomes.
Does subarachnoid hemorrhage impair endothelium-dependent relaxation in human basilar arteries?
Subarachnoid hemorrhage impairs endothelium-dependent relaxation in human basilar arteries within 1 day, suggesting endothelial dysfunction may contribute to delayed vasospasm.
Hatake et al. (1992) studied this question.
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