Population
Rat model of subarachnoid hemorrhage (SAH)
Comparison
Injection of 0.3 mL of autologous blood into the… vs Control and sham-operated animals
Design
Preclinical
Follow-up
20 min after blood injection
Authors
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Endothelial dysfunction may contribute to SAH spasm; hypothesis-generating for NOS3-targeted therapies pending human validation.
Subarachnoid hemorrhage induces acute microvascular endothelial dysfunction and decreases NOS3 protein levels, which may contribute to microvascular spasm.
Park et al. (2001) studied this question.
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