Key result
Human cerebral arterioles exhibit marked variability in reactivity to vasoactive agents and post-SAH fluids.
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✓ The capricious appearance of delayed cerebral vasospasm in some but not all patients with an aneurysmal subarachnoid hemorrhage (SAH) was the stimulus for studying the reactivity of human cerebral arterioles in vitro to various vasoactive agents (prostaglandin F 2a , noradrenaline, serotonin, human plasma, and cerebrospinal fluid from patients with aneurysmal SAH). There was a marked variability in response between arterioles from different individuals. The finding of a markedly individual profile in terms of reactivity toward vasoactive substances emphasizes the importance of a human cerebral vessel wall factor in the pathogenesis of cerebral vasospasm.
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Brandt et al. (1981) studied Aneurysmal subarachnoid hemorrhage (SAH). Vasoactive substances, human plasma, and CSF was evaluated on Reactivity of human cerebral arterioles in vitro. Human cerebral arterioles showed marked individual variability in their in vitro reactivity to various vasoactive agents, plasma, and cerebrospinal fluid from patients with aneurysmal SAH.
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