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February 24, 2011The FASEB Journal

Disrupted myosin cross‐bridge cycling kinetics triggers muscle weakness in nebulin‐related myopathy

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Authors

JOJulien OchalaUniversity of CopenhagenVLVilma‐Lotta LehtokariUniversity of HelsinkiHIHiroyuki IwamotoJapan Synchrotron Radiation Research Institute

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Implication

Disrupted cross-bridge kinetics may explain weakness in NEB myopathies; leaves open targeted therapies pending clinical validation.

Key Points

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Cite This Study

Ochala et al. (2011) studied this question.

synapsesocial.com/papers/6a70337e2163a0a01bc46a1ehttps://doi.org/10.1096/fj.10-176727
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Architecture of the sarcomere matrix of skeletal muscle: immunoelectron microscopic evidence that suggests a set of parallel inextensible nebulin filaments anchored at the Z line.1988 · 264 citations
  2. 2Nebulin Alters Cross-bridge Cycling Kinetics and Increases Thin Filament Activation2009 · 104 citations
  3. 3Sarcomere length‐tension relations of frog skinned muscle fibres during calcium activation at short lengths.1979 · 273 citations
  4. 4A myopathy-linked tropomyosin mutation severely alters thin filament conformational changes during activation2010 · 52 citations
  5. 5Reduced thin filament length in nebulin-knockout skeletal muscle alters isometric contractile properties2009 · 69 citations