Why the study?
Does activated protein C cross the blood-brain barrier via an EPCR-mediated mechanism in mice?
Population
Mouse models (including wild-type, severely deficient EPCR mice, and PAR1 null mice)
Comparison
Intravascular administration ofI-labeled… vs C-inulin reference tracer; wild-type controls…
Design
Preclinical
Authors
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May enable EPCR-targeted APC delivery in murine CNS models; leaves open human translation and therapeutic testing.
Does activated protein C cross the blood-brain barrier via an EPCR-mediated mechanism in mice?
Activated protein C and its variants cross the blood-brain barrier via an EPCR-mediated saturable transport mechanism, suggesting potential for central nervous system therapeutic targeting.
Deane et al. (2008) studied this question.
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