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February 4, 2021Scientific ReportsOpen Access

The aptamer BT200 blocks von Willebrand factor and platelet function in blood of stroke patients

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Why the study?

Conventional anti-platelet agents have limited efficacy in secondary stroke prevention under high shear stress with elevated VWF, prompting characterization of the anti-VWF aptamer BT200 in blood from patients with large artery atherosclerosis stroke.

Does BT200 inhibit VWF activity and platelet function in blood samples from patients with large artery atherosclerosis stroke?

Population

33 patients with acute stroke or transient ischemic attack

Comparison

Concentration-dependent effects of BT200 on blood samples

Design

Ex vivo laboratory study

Authors

KKKatarina D. KovacevicSGStefan GreiseneggerALA. Langer

Discussion

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Overview

BT200 inhibits VWF activity in acute stroke blood; leaves open efficacy for secondary prevention in prospective trials.

Structured PICO

Does BT200 inhibit VWF activity and platelet function in blood samples from patients with large artery atherosclerosis stroke?

P
Population
33 patients with acute stroke or transient ischemic attack (large artery atherosclerosis stroke)
I
Intervention
BT200 (a third-generation anti-VWF aptamer)
C
Comparator
Baseline (concentration-dependent analysis)
O
Outcome
Inhibition of VWF activity and VWF-dependent platelet function (ristocetin induced platelet aggregation, collagen adenosine diphosphate closure times)surrogate

The anti-VWF aptamer BT200 effectively inhibits VWF activity and platelet function in ex vivo blood samples from stroke patients, highlighting its potential as a novel antiplatelet agent for secondary stroke prevention.

Cite This Study

Kovacevic et al. (2021) studied this question.

synapsesocial.com/papers/6a703446e5469ee92be0f441https://doi.org/10.1038/s41598-021-82747-7
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Also Consider

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  5. 5Clopidogrel and Aspirin in Acute Ischemic Stroke and High-Risk TIA2018 · 1,365 citations