Two new gangliosides were isolated in pure form from beef brain. They were provisionally named ganglioside G5a and G5b. Ganglioside GSa is a monosialoganglioside containing fucose. Its basic neutral glycosphingolipid core is the gangliotetraose ceramide: Gal (1 —> 3) GalNac (1—> 4) Gal (1 —> 4) Glc (1—>) ceramide, most likely with β‐linkages. Fucose is linked to the 2‐position of external galactose, N ‐acetylneuraminic acid to the 3‐ position of internal galactose. Ganglioside G5b is a mixture of at least two isomeric disialogangliosides containing N ‐acetylneuraminic acid and N ‐glycolylneura‐minic acid. The major isomer has the following structure: NeuNac (α,2—>3) Gal (β,1—>3) GalNac (β, 1 —> 4) (NeuNglα, 2 —> 3) gal (β,1—>4) Glc (β,1 —>)‐ceramide. The minor isomer contains N ‐acetylneur‐aminic acid and N ‐glycolylneuraminic acid in an inverted linkage position.
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Ghidoni et al. (1976) studied this question.
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