Population
8 individuals (6 patients with hypertrophic cardiomyopathy and 2 healthy controls)
Comparison
DNA sequence analysis of the beta-myosin heavy… vs Healthy controls and reference sequence
Design
Case-control
Authors
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No causative MYH7 mutations found; leaves open contributions of other genes or modifiers and warrants larger multi-center sequencing studies.
Analysis of the MYH7 gene in a small cohort of HCM patients revealed several nucleotide substitutions but no definitive causative mutations, alongside normal kinetic behavior of the beta-MHC protein.
Wendel et al. (2000) studied this question.
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