Why the study?
Noroviruses cause a considerable gastroenteritis burden in China, and a better understanding of acquired immunity and immunological surrogate markers is urgently needed as vaccine candidates enter clinical evaluation.
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Norovirus is a major cause of acute gastroenteritis in China, highlighting the need for effective vaccines and immunological surrogate markers.
With the improvements of sanitation and nationwide safe water supply the occurrence of bacterial diarrhea declined remarkably, while viruses became the leading causes of acute gastroenteritis (AGE). Of these viruses, noroviruses (NoVs) are responsible for a considerable burden of gastroenteritis, especially in children < 2 years and elderly ⩾ 65 years. NoVs circulating in the Chinese population are antigenically highly diverse with the genotype GII.4 being the dominant strain followed by GII.3. Given the widespread contamination in environmental sources, and highly infectious nature of NoVs, vaccination would be the desirable strategy for the control of NoV infections. However, a better understanding of acquired immunity after infection, and a reliable immunological surrogate marker are urgently needed, since two vaccine candidates based on virus-like particles (VLPs) are currently moving into clinical evaluations in China.
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Zhou et al. (2019) studied this question.
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