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November 1, 1953Experimental Biology and Medicine

Angiotonin Induction of Vascular Lesions in Desoxycorticosterone-Treated Rats.

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Population

Rats pretreated with desoxycorticosterone (DCA) and salt

Design

Preclinical

Authors

GMG. M. C. MassonCentre National de la Recherche ScientifiqueACA. C. CorcoranChildren's Hospital of PhiladelphiaIPIrvine H. PagePennine Acute Hospitals NHS Trust

Discussion

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Implication

Angiotonin mediates renin-induced arteriolonecrosis in sensitized rats; extends mechanistic insight in animal models but leaves open human relevance.

Structured PICO

P
Population
Rats pretreated with desoxycorticosterone (DCA) and salt
I
Intervention
Hourly intraperitoneal administration of angiotonin or subcutaneous renin
O
Outcome
Development of edema, convulsions, positive fluid balance, increased fluid intake, proteinuria, visceral hemorrhages, and acute necrotizing lesions in small arteries and arteriolessurrogate

The study demonstrates that vascular lesions induced by renin in sensitized rats are likely mediated by the liberation of angiotonin.

Cite This Study

Masson et al. (1953) studied this question.

synapsesocial.com/papers/6a703803a2d7cf2e39c2a2bfhttps://doi.org/10.3181/00379727-84-20618
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Role of angiotensin II in cerebrovascular and renal damage in deoxycorticosterone acetate-salt hypertensive rats1995 · 45 citations
  2. 2Role of angiotensin II in renal injury of deoxycorticosterone acetate-salt hypertensive rats.1994 · 117 citations
  3. 3Effects of Deoxycorticosterone Acetate in Unilaterally Nephrectomized Dogs with Renal Artery Constriction1966 · 18 citations
  4. 4Effects of Angiotensin-Converting Enzyme Inhibitor and Angiotensin Type 1 Receptor Antagonist in Deoxycorticosterone Acetate–Salt Hypertensive Mice Lacking Ren-2 Gene2001 · 42 citations
  5. 5Mineralocorticoid Pretreatment Enhances Angiontensin II‐Induced Neuronal Excitation But Not Salt Drinking in Male Fischer Rats2006 · 4 citations