Why the study?
Does deoxycorticosterone acetate cause sustained sodium retention in unilaterally nephrectomized dogs with renal artery constriction?
Population
8 unilaterally nephrectomized dogs with renal artery constriction
Comparison
Deoxycorticosterone acetate 25 mg/day chronic… vs Baseline (before renal artery constriction)
Design
Preclinical
Authors
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Renal escape from DCA persists despite reduced GFR/RPF in dogs; leaves open hemodynamic roles in human mineralocorticoid hypertension.
Does deoxycorticosterone acetate cause sustained sodium retention in unilaterally nephrectomized dogs with renal artery constriction?
Renal hemodynamic alterations from renal artery constriction do not prevent the renal 'escape' from the sodium-retaining effects of deoxycorticosterone acetate in dogs.
Davis et al. (1966) studied this question.
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