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Zr-based MOF nanoparticles were applied as efficient carriers for alendronate delivery, and an unprecedented drug loading capacity was achieved thanks to the inherent drug anchorages of Zr-O clusters therein. The encapsulated drug featured with a pH-dependent release profile, and inhibited the growth of cancer cells more efficiently than the free drug.
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Zhu et al. (2014) studied this question.
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