Why the study?
The study was conducted to investigate the effect of rosuvastatin combined with propranolol on reducing migraine attacks.
Does rosuvastatin added to propranolol reduce migraine attacks in patients with migraine headache?
Does rosuvastatin added to propranolol reduce migraine attacks in patients with migraine headache?
The addition of rosuvastatin to propranolol significantly reduces the number of migraine attacks over 4 weeks compared to propranolol alone.
Supports adding rosuvastatin to propranolol for migraine prevention; extends evidence on statin adjunctive use.
Aim: To investigate the effect of rosuvastatin in combination with propranolol in reducing migraine attacks. Patients & methods: In a clinical trial study with census method, 120 patients with migraine headache were included. Patients were randomly assigned (using block randomization) to either propranolol (10 mg twice a day) with rosuvastatin (10 mg daily; intervention group [n = 60]) or propranolol (10 mg twice a day) with placebo (control [n = 60]). Results: The numbers of attacks were significantly decreased in the intervention group at the end of second, third and fourth weeks from the beginning of the intervention (p < 0.05). Conclusion: In patients with migraine, concomitant administration of propranolol (10 mg twice a day) and rosuvastatin (10 mg daily) is effective in reducing migraine attacks.
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Mazdeh et al. (2020) studied this question.
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