Why the study?
Does oral combined continuous hormone replacement therapy improve vascular function in healthy postmenopausal women?
Population
59 healthy postmenopausal women
Comparison
Oral combined continuous oestrogen and… vs Placebo
Design
RCT, randomized, double-blind, placebo-controlled
Follow-up
2 years
Authors
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Does not improve vascular function with oral combined HRT in healthy postmenopausal women; challenges presumed cardiovascular benefits.
Does oral combined continuous hormone replacement therapy improve vascular function in healthy postmenopausal women?
Long-term oral combined continuous hormone replacement therapy does not improve arterial compliance or endothelial function in healthy postmenopausal women, suggesting no cardiovascular benefit.
Teede et al. (2001) studied this question.
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