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September 9, 2010Proceedings of the National Academy of SciencesOpen Access

Effective shutdown in the expression of celiac disease-related wheat gliadin T-cell epitopes by RNA interference

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Population

Bread wheat and T-cell clones derived from the intestinal lesion of celiac disease patients

Design

Preclinical

Authors

JGJavier Gil‐HumanesUniversity of Minnesota SystemFPFernando PistónConsejo Superior de Investigaciones CientíficasSTStig TollefsenNorwegian Institute of Public Health

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Overview

Does not support dietary changes for celiac patients; leaves open RNAi wheat as a hypothesis-generating strategy.

Structured PICO

P
Population
Bread wheat and T-cell clones derived from the intestinal lesion of celiac disease patients
I
Intervention
RNA interference (RNAi) using hairpin constructs to down-regulate gliadin expression in bread wheat
O
Outcome
T-cell stimulation/response to total gluten protein extractssurrogate

Down-regulation of gliadins by RNAi in bread wheat significantly reduces T-cell responses, offering a potential strategy to develop wheat lines with low toxicity for celiac disease patients.

Cite This Study

Gil‐Humanes et al. (2010) studied this question.

synapsesocial.com/papers/6a703a6f8031ec7bb1dc3385https://doi.org/10.1073/pnas.1007773107
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