Why the study?
The lack of easily measurable biomarkers hinders clinical trials for diabetic neuropathy, and longitudinal studies evaluating plasma neurofilament light chain in diabetic neuropathy had not been performed.
Are elevated plasma neurofilament light chain concentrations associated with the development of diabetic neuropathy in youth-onset type 2 diabetes?
Comparison
50 participants who developed DN vs 50 participants who did not develop DN
Design
Nested case-control study
Authors
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NFL may identify DN in youth T2D; leaves open prospective validation before trial use.
Are elevated plasma neurofilament light chain concentrations associated with the development of diabetic neuropathy in youth-onset type 2 diabetes?
Plasma neurofilament light chain concentrations increase more rapidly in youth-onset type 2 diabetes patients who develop diabetic neuropathy, suggesting its potential as a predictive biomarker.
Fridman et al. (2023) studied this question.
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