What question did this study set out to answer?

To evaluate the impact of cigarette smoking status on the therapeutic efficacy and pharmacodynamic response of clopidogrel.

June 20, 2012JAMA

Clopidogrel Efficacy and Cigarette Smoking Status

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Clopidogrel response may differ by smoking status; leaves open whether status should guide agent selection or testing.

To evaluate the impact of cigarette smoking status on the therapeutic efficacy and pharmacodynamic response of clopidogrel.
Assessment of clopidogrel-mediated platelet inhibition and clinical outcomes stratified by patient smoking status.
Quantitative effect sizes and event rates were not reported in the provided text.

Gurbel et al. (2012) studied this question.

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