Physiological Response to Crystalloid Resuscitation of Severe Burns

S ummary The use of balanced salt solutions in the resuscitation of burn shock has been evaluated in experimental animals and clinical burns utilizing the maintenance of functional ECF volume and circulatory response as the criteria of effectiveness. In both animal and clinical burns restoration of the functional ECF required greater quantities administered at a faster rate than was anticipated. In the first 24–30 hr post‐burn, circulatory hemodynamics appear to be closely correlated with functional ECF volume maintenance. After this time, changes in the circulatory status seem to be unrelated to fluid administration.