The enzymic peptide synthesis in an organic medium was investigated by using papain in the presence of PEG. The added PEG enhanced the enzyme activity of papain for synthesis of the peptide, Boc-Gly-Asp(OBzl)OBzl. The activity of papain in the PEG-added system was higher than that in a PEG-free system.
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Hirano et al. (1991) studied this question.
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