Population
Sera from patients with chronic Chagas heart disease and systemic lupus erythematosus, and cardiomyocytes…
Comparison
Anti-P antibodies isolated from cChHD patients vs Anti-P autoantibodies from SLE patients
Design
Preclinical
Authors
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May link anti-P antibodies to cChHD pathogenesis; hypothesis-generating and should not yet change practice.
Anti-P antibodies in Chagas disease possess functional autoreactivity with heart tissue, suggesting their adrenergic-stimulating activity may contribute to myocardial impairments in chronic Chagas heart disease.
Kaplan et al. (1997) studied this question.
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