Key result
Quercetin outperforms verapamil in improving endothelial function despite similar blood pressure lowering in rats.
This study analysed and compared the effects of chronic oral treatment with quercetin or verapamil on systolic blood pressure and vascular function in deoxycorticosterone acetate (DOCA)-salt hypertensive rats. Quercetin and verapamil inhibited the development of DOCA-salt-induced hypertension in a similar manner. DOCA-salt-hypertensive rats showed potassium depletion and oxidative stress, prevented only by concomitant quercetin administration. Quercetin and verapamil treatments reduced the endothelium-independent hyper-reactivity to KCl observed in the aorta of DOCA-salt-hypertensive rats, but only quercetin increased the contractile responses to angiotensin II, improved endothelial dysfunction and restored basal aortic Cu/Zn SOD expression, altered in DOCA-salt-treated rats. In conclusion, quercetin and verapamil show similar antihypertensive effects in mineralocorticoid hypertension, but quercetin was superior to verapamil in improving endothelial-dependent aortic dilatation, suggesting a better vascular protection in this volume expansion hypertension model.
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Galisteo et al. (2004) studied Deoxycorticosterone acetate (DOCA)-salt hypertension. Quercetin vs. Verapamil was evaluated on Systolic blood pressure and vascular function. Quercetin was superior to verapamil in improving endothelial-dependent aortic dilatation in DOCA-salt hypertensive rats, despite demonstrating similar antihypertensive effects.
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