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Distinguishes actin-regulatory proteins in nonmuscle cells; leaves open their coordinated in vivo roles.
Microfilament organization, assembly, and turnover in nonmuscle cells involves a number of regulatory as well as structural proteins. For some time it seemed sensible to distinguish betwen F-actin-stabilizing pro-teins such as tropomyosin (Lazarides and Burridge 1975), long flexible gelation factors such as filamin (Wang et al. 1975; Brotschi et al. 1979), and rather globular bundling proteins such as fascin (Bryan and
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Weber et al. (1982) studied this question.
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