June 15, 2007BiochemistryOpen Access

Tropomyosin Regulates Elongation by Formin at the Fast-Growing End of the Actin Filament

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Population

In vitro actin filaments and protein constructs (FRL1, mDia1, mDia2)

Design

Preclinical

Authors

BWBarbara WawroInstytut Biologii Doświadczalnej im. Marcelego Nenckiego NGNorma J. GreenfieldRutgers, The State University of New Jersey MWMartin A. WearWellcome Centre for Cell Biology

Discussion

Member takes

Implication

Hypothesis-generating for actin dynamics in cardiovascular cells; leaves open clinical translation from this animal biochemistry.

Structured PICO

Population

In vitro actin filaments and protein constructs (FRL1, mDia1, mDia2)

Intervention

Tropomyosin

Outcome

Regulation of dynamics at the barbed end of actin filaments

Tropomyosin functions as an activator of formin, regulating actin filament elongation at the fast-growing end and establishing it as a universal regulator of the actin cytoskeleton.

Cite This Study

Wawro et al. (2007) studied this question.

synapsesocial.com/papers/6a849c0b192ab555d8a90773 https://doi.org/10.1021/bi700686p

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Tropomyosin Regulates Elongation by Formin at the Fast-Growing End of the Actin Filament

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Tropomyosin Regulates Elongation by Formin at the Fast-Growing End of the Actin Filament

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider