January 21, 2013Clinical and Experimental Pharmacology and PhysiologyOpen Access

Distinct regulation of inner medullary collecting duct nitric oxide production from mice and rats

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Population

Male C57blk/J6 mice and Sprague-Dawley rats

Comparison

4% (high salt; HS) NaCl diet for 2 or 7 days vs 0.4% (normal salt; NS) NaCl diet

Design

Preclinical

Follow-up

2 or 7 days

Authors

KHKelly A. HyndmanUniversity of Alabama at Birmingham JXJing XueHainan Modern Women and Children's Hospital AMAlexander H. MacDonellAugusta University

Discussion

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Implication

Species differences in renal NO production caution against extrapolating rodent high-salt data to humans; leaves open NOS1 variant roles in human salt sensitivity.

Structured PICO

Population

Male C57blk/J6 mice and Sprague-Dawley rats

Intervention

4% (high salt; HS) NaCl diet for 2 or 7 days

Comparator

0.4% (normal salt; NS) NaCl diet

Outcome

Urinary excretion of nitrate/nitrite (NO(x)), IMCD nitrite production, and expression of NOS1 splice variants and NOS3surrogate

This study demonstrates species-specific differences in the regulation of inner medullary collecting duct nitric oxide production and NOS1 splice variant expression in response to high dietary sodium.

Cite This Study

Hyndman et al. (2013) studied this question.

synapsesocial.com/papers/6a703d396c240de38cdbba4b https://doi.org/10.1111/1440-1681.12057

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Implication

Species differences in renal NO production caution against extrapolating rodent high-salt data to humans; leaves open NOS1 variant roles in human salt sensitivity.

Distinct regulation of inner medullary collecting duct nitric oxide production from mice and rats

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Distinct regulation of inner medullary collecting duct nitric oxide production from mice and rats

Discussion

Member takes

Implication

Structured PICO

Cite This Study

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Also Consider